4-Mesylphenylacetic acid → HCID 53238660, compound

HRID 469612Notes

Reaction equation

HRID 469612 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:19].[CH3:20][S:21]([C:24]1[CH:29]=[CH:28][C:27]([CH2:30][C:31](O)=[O:32])=[CH:26][CH:25]=1)(=[O:23])=[O:22]>>[Cl:18][C:15]1[CH:16]=[CH:17][C:12]([C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3](=[O:19])[N:2]([NH:1][C:31](=[O:32])[CH2:30][C:27]3[CH:26]=[CH:25][C:24]([S:21]([CH3:20])(=[O:22])=[O:23])=[CH:29][CH:28]=3)[N:11]=2)=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 5723454-Mesylphenylacetic acidHCID 671613672-amino-4-(4-chlorophenyl)phthalazin-1(2H)-one

Product 1

HCID 53238660HCID 53238660, compound

Procedure

The product of Example 86A and 2-[4-(methylsulfonyl)phenyl]acetic acid were treated using a method similar to that described in Example 57 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.40-8.43 (m, 1H), 7.95-8.02 (m, 2H), 7.90-7.94 (m, 2H), 7.72-7.75 (m, 1H), 7.65-7.68 (m, 2H), 7.61-7.66 (m, 4H), 3.86 (s, 2H), 3.20 (s, 3H); MS (ESI−) M/Z 466 (M−H)−.

Sources & evidence

ORD record
ord-27569f5b7254411a8475c837a0f87413
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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