1-Adamantaneacetic acid → HCID 53238434, compound

HRID 469616Notes

Reaction equation

HRID 469616 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:19].[C:20]12([CH2:30][C:31](O)=[O:32])[CH2:29][CH:24]3[CH2:25][CH:26]([CH2:28][CH:22]([CH2:23]3)[CH2:21]1)[CH2:27]2>>[C:20]12([CH2:30][C:31]([NH:1][N:2]3[N:11]=[C:10]([C:12]4[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=4)[C:9]4[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=4)[C:3]3=[O:19])=[O:32])[CH2:27][CH:26]3[CH2:25][CH:24]([CH2:23][CH:22]([CH2:28]3)[CH2:21]1)[CH2:29]2

Participants

3

Reactant 2

HCID 1232211-Adamantaneacetic acidHCID 671613672-amino-4-(4-chlorophenyl)phthalazin-1(2H)-one

Product 1

HCID 53238434HCID 53238434, compound

Procedure

The product of Example 86A and 2-(adamantan-1-yl)acetic acid were processed using a method similar to that described in Example 17C to afford the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.18-11.35 (bs, 1H), 8.39-8.42 (m, 1H), 7.89-8.02 (m, 2H), 7.70-7.73 (m, 1H), 7.56-7.68 (m, 4H), 2.04 (s, 2H), 1.92-1.95 (m, 3H), 1.66-1.69 (m, 6H), 1.63-1.70 (m, 3H), 1.57-1.62 (m, 3H); MS (ESI+) m/z 448 (M+H)+.

Sources & evidence

ORD record
ord-5579eb0b3e9f4a80855806acfbbfeb57
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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