3,5-Difluorophenylacetic acid → HCID 67161293, compound

HRID 469618Notes

Reaction equation

HRID 469618 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:19].[F:20][C:21]1[CH:22]=[C:23]([CH2:28][C:29](O)=[O:30])[CH:24]=[C:25]([F:27])[CH:26]=1>>[Cl:18][C:15]1[CH:16]=[CH:17][C:12]([C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3](=[O:19])[N:2]([NH:1][C:29](=[O:30])[CH2:28][C:23]3[CH:22]=[C:21]([F:20])[CH:26]=[C:25]([F:27])[CH:24]=3)[N:11]=2)=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 1454243,5-Difluorophenylacetic acidHCID 671613672-amino-4-(4-chlorophenyl)phthalazin-1(2H)-one

Product 1

HCID 67161293HCID 67161293, compound

Procedure

The product of Example 86A and 2-(3,5-difluorophenyl)acetic acid were processed using a method similar to that described in Example 17C to afford the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.77-11.78 (bs, 1H), 8.39-8.42 (m, 1H), 7.89-8.03 (m, 2H), 7.69-7.74 (m, 1H), 7.60-7.65 (m, 4H), 7.06-7.20 (m, 3H), 3.76 (s, 2H); MS (ESI+) m/z 426 (M+H)+.

Sources & evidence

ORD record
ord-3e30f822589d49ebab4f4e01a2d01305
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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