1-Naphthaleneacetic Acid → HCID 67162542, compound

HRID 469621Notes

Reaction equation

HRID 469621 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:19].[C:20]1([CH2:30][C:31](O)=[O:32])[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:23]=[CH:22][CH:21]=1>>[Cl:18][C:15]1[CH:16]=[CH:17][C:12]([C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3](=[O:19])[N:2]([NH:1][C:31](=[O:32])[CH2:30][C:20]3[C:29]4[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=4)[CH:23]=[CH:22][CH:21]=3)[N:11]=2)=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 68621-Naphthaleneacetic AcidHCID 671613672-amino-4-(4-chlorophenyl)phthalazin-1(2H)-one

Product 1

HCID 67162542HCID 67162542, compound

Procedure

The product from Example 86A and 2-(1-naphthyl)acetic acid were treated using a method similar to that described in Example 57 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.40-8.43 (m, 1H), 8.18 (d, J=8.2 Hz, 1H), 7.95-8.01 (m, 3H), 7.88 (d, J=8.1 Hz, 1H), 7.70-7.77 (m, 1H), 7.61-7.66 (m, 4H), 7.54-7.60 (m, 3H), 7.51 (dd, J=8.2, 7.1 Hz, 1H), 4.19 (s, 2H); MS (ESI−) M/Z 438 (M−H)−.

Sources & evidence

ORD record
ord-6ff75ead4ecb422fb54754b35ad9daca
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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