(4-Chlorophenyl)acetic acid → HCID 53236387, compound

HRID 469638Notes

Reaction equation

HRID 469638 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:20].[Cl:21][C:22]1[CH:27]=[CH:26][C:25]([CH2:28][C:29](O)=[O:30])=[CH:24][CH:23]=1>>[Cl:19][C:16]1[CH:15]=[CH:14][C:13]([CH2:12][C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3](=[O:20])[N:2]([NH:1][C:29](=[O:30])[CH2:28][C:25]3[CH:26]=[CH:27][C:22]([Cl:21])=[CH:23][CH:24]=3)[N:11]=2)=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 15880(4-Chlorophenyl)acetic acidHCID 67162101HCID 67162101, compound

Product 1

HCID 53236387HCID 53236387, compound

Procedure

The product of Example 144A and 2-(4-chlorophenyl)acetic acid were treated using a method similar to that described in Example 17C to give the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.63 (s, 1H), 8.30 (d, J=8.3 Hz, 1H), 7.95-7.99 (m, 1H), 7.90-7.95 (m, 1H), 7.84-7.89 (m, 1H), 7.37-7.44 (m, 4H), 7.31-7.38 (m, 4H), 4.32-4.32 (bs, 2H), 3.70 (s, 2H); LC/MS (APCI) M/Z 438 (M+H)+.

Sources & evidence

ORD record
ord-0d8c4732572149d3bb7f5424ddeb8382
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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