3,5-Difluorophenylacetic acid → HCID 53236157, compound

HRID 469639Notes

Reaction equation

HRID 469639 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:20].[F:21][C:22]1[CH:23]=[C:24]([CH2:29][C:30](O)=[O:31])[CH:25]=[C:26]([F:28])[CH:27]=1>>[Cl:19][C:16]1[CH:15]=[CH:14][C:13]([CH2:12][C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3](=[O:20])[N:2]([NH:1][C:30](=[O:31])[CH2:29][C:24]3[CH:23]=[C:22]([F:21])[CH:27]=[C:26]([F:28])[CH:25]=3)[N:11]=2)=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 1454243,5-Difluorophenylacetic acidHCID 67162101HCID 67162101, compound

Product 1

HCID 53236157HCID 53236157, compound

Procedure

The product of Example 144A and 2-(3,5-difluorophenyl)acetic acid were treated using a method similar to that described in Example 17C to give the title compound. 1H NMR (500 MHz, DMSO-d6) δ ppm 11.68 (s, 1H), 8.32 (dd, J=7.9, 1.4 Hz, 1H), 7.98 (d, J=7.9 Hz, 1H), 7.91-7.95 (m, 1H), 7.85-7.89 (m, 1H), 7.32-7.38 (m, 4H), 7.11-7.19 (m, 3H), 4.33 (s, 2H), 3.76 (s, 2H); LC/MS (APCI) M/Z 440 (M+H)+.

Sources & evidence

ORD record
ord-cb79129bde3142c3bb3539bc83c3cdce
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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