2-(3,5-Difluorophenyl)acetyl chloride → 2-(3,5-difluorophenyl)-N-[4-(4-methoxyphenyl)-1-oxophthalazin-2(1H)-yl]acetamide

Participants

Role	Name	HCID	Charge
Reactant	2-(3,5-Difluorophenyl)acetyl chloride	HCID 2782723	—
Reactant	2-amino-4-(4-methoxyphenyl)phthalazin-1(2H)-one	HCID 67160105	—
Product	2-(3,5-difluorophenyl)-N-[4-(4-methoxyphenyl)-1-oxophthalazin-2(1H)-yl]acetamide	HCID 53236154	—

Reaction Steps

The product from Example 151A and 2-(3,5-difluorophenyl)acetyl chloride were treated using a method similar to that described in Example 1C to give the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 11.73 (s, 1H), 8.39-8.42 (m, 1H), 7.87-8.05 (m, 2H), 7.75-7.79 (m, 1H), 7.52-7.55 (m, 2H), 7.05-7.23 (m, 5H), 3.85 (s, 3H), 3.77 (s, 2H); MS (ESI+) M/Z 422 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08629143B2
Source dataset	uspto-grants-2014_01
ORD ID	ord-e0cd0418422541769c59a31ed48a5c1e
Source note	uspto-grants-2014_01