3,5-Difluorophenylacetic acid → HCID 53236390, compound

HRID 469649Notes

Reaction equation

HRID 469649 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][C:13]=2[CH3:19])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:20].[F:21][C:22]1[CH:23]=[C:24]([CH2:29][C:30](O)=[O:31])[CH:25]=[C:26]([F:28])[CH:27]=1>>[F:21][C:22]1[CH:23]=[C:24]([CH2:29][C:30]([NH:1][N:2]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][C:13]=3[CH3:19])[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:20])=[O:31])[CH:25]=[C:26]([F:28])[CH:27]=1

Participants

3

Reactant 2

HCID 1454243,5-Difluorophenylacetic acidHCID 67161053HCID 67161053, compound

Product 1

HCID 53236390HCID 53236390, compound

Procedure

The product of Example 159A and 2-(3,5-difluorophenyl)acetic acid were treated using a method similar to that described in Example 17C to give the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.67-11.81 (bs, 1H), 8.38-8.41 (m, 1H), 7.85-7.98 (m, 2H), 7.25-7.32 (m, 1H), 7.20-7.24 (m, 2H), 7.09-7.19 (m, 4H), 3.75 (s, 2H), 2.37 (s, 3H), 2.05 (s, 3H); MS (APCI+) M/Z 420 (M+H)+.

Sources & evidence

ORD record
ord-339d53fea80646e7aaca7adcb1b58510
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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