(4-Chlorophenyl)acetic acid → HCID 53236621, compound

HRID 469652Notes

Reaction equation

HRID 469652 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[C:14]([CH3:19])[CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:20].[Cl:21][C:22]1[CH:27]=[CH:26][C:25]([CH2:28][C:29](O)=[O:30])=[CH:24][CH:23]=1>>[Cl:21][C:22]1[CH:27]=[CH:26][C:25]([CH2:28][C:29]([NH:1][N:2]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([CH3:18])=[C:14]([CH3:19])[CH:13]=3)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:20])=[O:30])=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 15880(4-Chlorophenyl)acetic acidHCID 67160611HCID 67160611, compound

Product 1

HCID 53236621HCID 53236621, compound

Procedure

The product of Example 163A and 2-(4-chlorophenyl)acetic acid were treated using a method similar to that described in Example 17C to give the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.69 (s, 1H), 8.38-8.40 (m, 1H), 7.88-8.02 (m, 2H), 7.74 (d, J=6.5 Hz, 1H), 7.38-7.44 (m, 4H), 7.33-7.36 (m, 1H), 7.27-7.33 (m, 2H), 3.70 (s, 2H), 2.32 (s, 3H), 2.31 (s, 3H); MS (APCI+) M/Z 418 (M+H)+.

Sources & evidence

ORD record
ord-d4cc98bacc8647de95d902102854bb4c
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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