3,5-Difluorophenylacetic acid → HCID 53236391, compound

HRID 469653Notes

Reaction equation

HRID 469653 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[C:14]([CH3:19])[CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:20].[F:21][C:22]1[CH:23]=[C:24]([CH2:29][C:30](O)=[O:31])[CH:25]=[C:26]([F:28])[CH:27]=1>>[F:21][C:22]1[CH:23]=[C:24]([CH2:29][C:30]([NH:1][N:2]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([CH3:18])=[C:14]([CH3:19])[CH:13]=3)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:20])=[O:31])[CH:25]=[C:26]([F:28])[CH:27]=1

Participants

3

Reactant 2

HCID 1454243,5-Difluorophenylacetic acidHCID 67160611HCID 67160611, compound

Product 1

HCID 53236391HCID 53236391, compound

Procedure

The product of Example 163A and 2-(3,5-difluorophenyl)acetic acid were treated using a method similar to that described in Example 17C to give the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.74 (s, 1H), 8.39-8.42 (m, 1H), 7.89-8.02 (m, 2H), 7.74-7.77 (m, 1H), 7.25-7.39 (m, 3H), 7.12-7.18 (m, 3H), 3.77 (s, 2H), 2.32 (s, 3H), 2.31 (s, 3H); MS (APCI+) M/Z 420 (M+H)+.

Sources & evidence

ORD record
ord-0e3bb4e220094ef9b3130422c6deb6f4
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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