3,5-Difluorophenylacetic acid → HCID 53236622, compound

HRID 469658Notes

Reaction equation

HRID 469658 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([CH:18]([CH3:20])[CH3:19])=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:21].[F:22][C:23]1[CH:24]=[C:25]([CH2:30][C:31](O)=[O:32])[CH:26]=[C:27]([F:29])[CH:28]=1>>[F:22][C:23]1[CH:24]=[C:25]([CH2:30][C:31]([NH:1][N:2]2[N:11]=[C:10]([C:12]3[CH:13]=[CH:14][C:15]([CH:18]([CH3:19])[CH3:20])=[CH:16][CH:17]=3)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:21])=[O:32])[CH:26]=[C:27]([F:29])[CH:28]=1

Participants

3

Reactant 2

HCID 1454243,5-Difluorophenylacetic acidHCID 67160201HCID 67160201, compound

Product 1

HCID 53236622HCID 53236622, compound

Procedure

The product of Example 168A and 2-(3,5-difluorophenyl)acetic acid were treated using a method similar to that described in Example 17C to give the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.70-11.81 (m, 1H), 8.40-8.42 (m, 1H), 7.89-8.03 (m, 2H), 7.75-7.78 (m, 1H), 7.51-7.53 (m, 2H), 7.43-7.46 (m, 2H), 7.07-7.22 (m, 3H), 3.77 (s, 2H), 2.94-3.07 (m, 1H), 1.27 (d, J=6.9 Hz, 6H); MS (APCI+) M/Z 434 (M+H)+.

Sources & evidence

ORD record
ord-64f01f3ccc4c4eba97d3c456d002d07b
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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