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HRID469661

反应详情

EQUATION

反应方程式

HRID 469661 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)N
HCID6385

tert-Butylamine

C4H11N

结构：O=C1OC(=O)c2cc(C(F)(F)F)ccc21
HCID12717789

5-(Trifluoromethyl)-2-benzofuran-1,3-dione

C9H3F3O3

PRODUCTS

生成物

1
结构：CC(C)(C)N1C(=O)c2ccc(C(F)(F)F)cc2C1=O
HCID67160286

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(=O)O
溶剂HCID176

Acetic Acid

C2H4O2

CONDITIONS

反应条件

温度
100 °C

PROCEDURE

实验过程

A suspension of 5-(trifluoromethyl)isobenzofuran-1,3-dione and 2-methylpropan-2-amine in acetic acid was heated at 100° C. overnight, concentrated, diluted with EtOAc, washed with saturated aqueous NaHCO3 and brine, dried (Na2SO4), filtered, and concentrated to give crude 2-tert-butyl-5-(trifluoromethyl)isoindoline-1,3-dione, which was used without purification.

WORKUP

后处理

  1. concentrationconcentrated
  2. additiondiluted with EtOAc
  3. washwashed with saturated aqueous NaHCO3 and brine
  4. dry with materialdried (Na2SO4)
  5. filtrationfiltered
  6. concentrationconcentrated