Hydrazine → HCID 67161250, compound

HRID 469662Notes

Reaction equation

C([N:5]1[C:13](=[O:14])[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:15]([F:18])([F:17])[F:16])[CH:11]=2)[C:6]1=O)(C)(C)C.[CH:20]([Mg]Br)([CH3:22])[CH3:21].[NH2:25][NH2:26].C1(P(ON)(C2C=CC=CC=2)=O)C=CC=CC=1>>[NH2:25][N:26]1[N:5]=[C:6]([CH:20]([CH3:22])[CH3:21])[C:7]2[C:12](=[CH:11][C:10]([C:15]([F:16])([F:17])[F:18])=[CH:9][CH:8]=2)[C:13]1=[O:14]

Participants

Reactant 4

HCID 9321Hydrazine

HCID 10955453O-(Diphenylphosphinyl)hydroxylamine

HCID 67160286HCID 67160286, compound

HCID 178418365HCID 178418365, compound

Product 1

HCID 67161250HCID 67161250, compound

Procedure

The crude 2-tert-butyl-5-(trifluoromethyl)isoindoline-1,3-dione was treated with isopropylmagnesium bromide and hydrazine using a method similar to that described in Example 1A, followed by treatment with O-(diphenylphosphoryl)hydroxylamine using a method similar to that described in Example 1B to give the title compound. LC/MS (APCI) m/z 272 (M+H)+.

Sources & evidence

ORD record: ord-50cf0c1154274c1084aeaf8d5306bc1a
Source dataset: uspto-grants-2014_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08629143B2

Reaction notes

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