HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Adamantaneacetyl chloride → 2-(adamantan-1-yl)-N-[4-isopropyl-1-oxo-7-(trifluoromethyl)phthalazin-2(1H)-yl]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Adamantaneacetyl chloride | HCID 2771882 | — |
| Reactant | HCID 67161250 | HCID 67161250 | — |
| Product | 2-(adamantan-1-yl)-N-[4-isopropyl-1-oxo-7-(trifluoromethyl)phthalazin-2(1H)-yl]acetamide | HCID 67161539 | — |
Reaction Steps
The product from Example 173A and 2-(adamantan-1-yl)acetyl chloride were treated as in Example 1C to give the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 11.19-11.28 (m, 1H), 8.58 (s, 1H), 8.28-8.40 (m, 2H), 3.58-3.70 (m, 1H), 2.04 (s, 2H), 1.93-1.98 (bs, 3H), 1.55-1.75 (m, 12H), 1.27 (d, J=6.7 Hz, 6H); MS (ESI+) M/Z 448 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08629143B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-c7db735cca054d86a6582d1e31a94a93 |
| Source note | uspto-grants-2014_01 |