HuagongsheHuagongshe Chemistry Print Report · For research reference only
(Methylthio)acetic acid → 2-(methylthio)-N-[1-oxo-4-(trifluoromethyl)phthalazin-2(1H)-yl]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (Methylthio)acetic acid | HCID 75551 | — |
| Reactant | 2-amino-4-(trifluoromethyl)phthalazin-1(2H)-one | HCID 67161111 | — |
| Product | 2-(methylthio)-N-[1-oxo-4-(trifluoromethyl)phthalazin-2(1H)-yl]acetamide | HCID 67160737 | — |
Reaction Steps
The product from Example 11B and 2-(methylthio)acetic acid were treated using a method similar to that described in Example 57 to give the title compound 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.45 (ddd, J=8.0, 1.4, 0.7 Hz, 1H), 8.15 (td, J=7.7, 1.4 Hz, 1H), 8.04-8.11 (m, 2H), 3.37 (s, 2H), 2.24 (s, 3H); MS (ESI−) M/Z 316 (M−H)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08629143B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-97ea81dbc52f4922b57cf1c1c2b62428 |
| Source note | uspto-grants-2014_01 |