反应详情

(S)-1-(4-nitro-phenyl)-5-oxo-pyrrolidine-2-carboxylic acid tert-butyl ester (800 mg, 2.6 mmol) is treated with trifluoroacetic acid (5 mL) at room temperature. After 1 h trifluoroacetic acid is evaporated in vacuo and the concentrate treated with ice/water. Precipitated light brownish solid is filtered washed with water and dried to give the title compound, ESI m/z 251 [M+H]+.

1. customAfter 1 h trifluoroacetic acid is evaporated in vacuo
2. additionthe concentrate treated with ice/water
3. customPrecipitated light brownish solid
4. filtrationis filtered
5. washwashed with water
6. customdried