反应详情

(S)-1-(3-Chloro-5-trifluoromethyl-pyridin-2-yl)-5-oxo-pyrrolidine-2-carboxylic acid tert-butyl ester (760 mg, 2.1 mmol) is treated with pre-cooled trifluoroacetic acid (5 mL). The clear solution is kept at room temperature for 1 h. Trifluoroacetic acid is evaporated in vacuo and the concentrate is treated with ice/water. Precipitated white solid is filtered, washed with water to give the title compound, ESI m/z 309 [M+H]+.

1. customTrifluoroacetic acid is evaporated in vacuo
2. additionthe concentrate is treated with ice/water
3. customPrecipitated white solid
4. filtrationis filtered
5. washwashed with water