反应详情

5-Cyclohex-1-enyl-N-(pyridin-3-yl)-6-(2,2,2-trifluoroethoxy)nicotinamide (Example 1c, 0.012 g, 31.8 μmol) was dissolved in ethyl acetate (1 mL). Palladium (10% on charcoal, 3.4 mg, 32 μmol) was added; the suspension was degassed and aerated with argon (5×). Then it was degassed and aerated with hydrogen (3×) and stirred for 20 h under hydrogen. The reaction mixture was degassed and aerated with argon (3×) again. Then it was filtered through dicalite, washed with i-propyl acetate and concentrated in vacuo to give the title compound (11 mg, 91%) as white solid; MS (ESI) 380.3 (M+H)+.

1. customthe suspension was degassed
2. customThen it was degassed
3. customThe reaction mixture was degassed
4. filtrationThen it was filtered through dicalite
5. washwashed with i-propyl acetate
6. concentrationconcentrated in vacuo