2-(Cyclopent-1-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane → 5-cyclopent-1-enyl-N-pyridin-3-yl-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

HRID 469778Notes

Reaction equation

HRID 469778 reaction equation
I[C:2]1[C:3]([O:17][CH2:18][C:19]([F:22])([F:21])[F:20])=[N:4][CH:5]=[C:6]([CH:16]=1)[C:7]([NH:9][C:10]1[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=1)=[O:8].[C:23]1(B2OC(C)(C)C(C)(C)O2)[CH2:27][CH2:26][CH2:25][CH:24]=1>>[C:23]1([C:2]2[C:3]([O:17][CH2:18][C:19]([F:22])([F:21])[F:20])=[N:4][CH:5]=[C:6]([CH:16]=2)[C:7]([NH:9][C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)=[O:8])[CH2:27][CH2:26][CH2:25][CH:24]=1

Participants

3

Reactant 2

HCID 154866112-(Cyclopent-1-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneHCID 712943625-Iodo-N-(pyridin-3-yl)-6-(2,2,2-trifluoroethoxy)nicotinamide

Product 1

HCID 712941125-cyclopent-1-enyl-N-pyridin-3-yl-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

Procedure

The title compound was synthesized in analogy to Example 1c using 5-iodo-N-(pyridin-3-yl)-6-(2,2,2-trifluoroethoxy)nicotinamide (Example 1b) and 2-(1-cyclopenten-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAN 287944-10-9) as starting materials; MS (ESI) 364.4 (M+H)+.

Sources & evidence

ORD record
ord-86c217c312484c519c2d4a2c13cc446b
Source dataset
uspto-grants-2014_01
Patent number
US08629166B2

Reaction notes

Loading…