2-Aminopyridine → 5-cyclopentyl-N-pyridin-2-yl-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

HRID 469781Notes

Reaction equation

HRID 469781 reaction equation
[CH:1]1([C:6]2[C:7]([O:15][CH2:16][C:17]([F:20])([F:19])[F:18])=[N:8][CH:9]=[C:10]([CH:14]=2)[C:11]([OH:13])=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.[N:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[NH2:27]>>[CH:1]1([C:6]2[C:7]([O:15][CH2:16][C:17]([F:20])([F:19])[F:18])=[N:8][CH:9]=[C:10]([CH:14]=2)[C:11]([NH:27][C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][N:21]=2)=[O:13])[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

3

Reactant 2

HCID 104392-AminopyridineHCID 712941865-Cyclopentyl-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid

Product 1

HCID 712945605-cyclopentyl-N-pyridin-2-yl-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

Procedure

The title compound was synthesized in analogy to Example 1b using 5-cyclopentyl-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid (Example 9c) and 2-pyridinamine (CAN 504-29-0) as starting materials; MS (ESI) 366.2 (M+H)+.

Sources & evidence

ORD record
ord-bcb3cf8396ea4f15ae5e79638a491250
Source dataset
uspto-grants-2014_01
Patent number
US08629166B2

Reaction notes

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