3-Methoxy-5-isoxazolemethanamine → 5-cyclohexyl-N-(3-methoxy-isoxazol-5-ylmethyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

HRID 469784Notes

Reaction equation

HRID 469784 reaction equation
[CH:1]1([C:7]2[C:8]([O:16][CH2:17][C:18]([F:21])([F:20])[F:19])=[N:9][CH:10]=[C:11]([CH:15]=2)[C:12]([OH:14])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:22][O:23][C:24]1[CH:28]=[C:27]([CH2:29][NH2:30])[O:26][N:25]=1>>[CH:1]1([C:7]2[C:8]([O:16][CH2:17][C:18]([F:21])([F:20])[F:19])=[N:9][CH:10]=[C:11]([CH:15]=2)[C:12]([NH:30][CH2:29][C:27]2[O:26][N:25]=[C:24]([O:23][CH3:22])[CH:28]=2)=[O:14])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 27632273-Methoxy-5-isoxazolemethanamineHCID 712939525-Cyclohexyl-6-(2,2,2-trifluoroethoxy)nicotinic acid

Product 1

HCID 712944525-cyclohexyl-N-(3-methoxy-isoxazol-5-ylmethyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

Procedure

This compound was prepared following the same procedure as described in Example 11 using 5-cyclohexyl-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid (Example 4b) (120 mg, 0.4 mmol) and 3-methoxy-5-isoxazolemethanamine (CAN 2763-94-2) (60.16 mg, 0.47 mmol) as starting materials; off white solid (32 mg, 19.6%). MS (ESI): 414 (M+H)+.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-a75f2208130c45db873114b2f1a80a4a
Source dataset
uspto-grants-2014_01
Patent number
US08629166B2

Reaction notes

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