HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methoxy-5-isoxazolemethanamine → 5-cyclohexyl-N-(3-methoxy-isoxazol-5-ylmethyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methoxy-5-isoxazolemethanamine | HCID 2763227 | — |
| Reactant | 5-Cyclohexyl-6-(2,2,2-trifluoroethoxy)nicotinic acid | HCID 71293952 | — |
| Product | 5-cyclohexyl-N-(3-methoxy-isoxazol-5-ylmethyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide | HCID 71294452 | — |
Reaction Steps
This compound was prepared following the same procedure as described in Example 11 using 5-cyclohexyl-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid (Example 4b) (120 mg, 0.4 mmol) and 3-methoxy-5-isoxazolemethanamine (CAN 2763-94-2) (60.16 mg, 0.47 mmol) as starting materials; off white solid (32 mg, 19.6%). MS (ESI): 414 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08629166B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-a75f2208130c45db873114b2f1a80a4a |
| Source note | uspto-grants-2014_01 |