(2-Cyclopropylthiazol-4-yl)methanamine → 5-cyclopentyl-N-(2-cyclopropyl-thiazol-4-ylmethyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

HRID 469791Notes

Reaction equation

HRID 469791 reaction equation
[CH:1]1([C:6]2[C:7]([O:15][CH2:16][C:17]([F:20])([F:19])[F:18])=[N:8][CH:9]=[C:10]([CH:14]=2)[C:11]([OH:13])=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:21]1([C:24]2[S:25][CH:26]=[C:27]([CH2:29][NH2:30])[N:28]=2)[CH2:23][CH2:22]1>>[CH:1]1([C:6]2[C:7]([O:15][CH2:16][C:17]([F:20])([F:19])[F:18])=[N:8][CH:9]=[C:10]([CH:14]=2)[C:11]([NH:30][CH2:29][C:27]2[N:28]=[C:24]([CH:21]3[CH2:23][CH2:22]3)[S:25][CH:26]=2)=[O:13])[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

3

Reactant 2

HCID 45792629(2-Cyclopropylthiazol-4-yl)methanamineHCID 712941865-Cyclopentyl-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid

Product 1

HCID 712945075-cyclopentyl-N-(2-cyclopropyl-thiazol-4-ylmethyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

Procedure

This compound was prepared following the same procedure as described in Example 11 using 5-cyclopentyl-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid (Example 9c) (100 mg, 0.35 mmol) and 2-cyclopropyl-4-thiazolemethanamine (CAN 1083299-53-9, 54 mg, 0.35 mmol) as starting materials; off white solid (67 mg, 45.6%). MS (ESI): 426 (M+H)+.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-ec6774a9d5a34ec6ac696a626824ddc0
Source dataset
uspto-grants-2014_01
Patent number
US08629166B2

Reaction notes

Loading…