(2-Cyclopropylthiazol-4-yl)methanamine → 5-cyclopentyl-N-(2-cyclopropyl-thiazol-4-ylmethyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

Participants

Reaction Steps

This compound was prepared following the same procedure as described in Example 11 using 5-cyclopentyl-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid (Example 9c) (100 mg, 0.35 mmol) and 2-cyclopropyl-4-thiazolemethanamine (CAN 1083299-53-9, 54 mg, 0.35 mmol) as starting materials; off white solid (67 mg, 45.6%). MS (ESI): 426 (M+H)+.

Provenance & Evidence