4-Aminopyrimidine → HCID 71294419, compound

HRID 469796Notes

Reaction equation

HRID 469796 reaction equation
[CH:1]1([C:6]2[C:7]([O:15][CH2:16][C:17]([F:20])([F:19])[F:18])=[N:8][CH:9]=[C:10]([CH:14]=2)[C:11]([OH:13])=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.[N:21]1[CH:26]=[CH:25][C:24]([NH2:27])=[N:23][CH:22]=1>>[CH:1]1([C:6]2[C:7]([O:15][CH2:16][C:17]([F:20])([F:19])[F:18])=[N:8][CH:9]=[C:10]([CH:14]=2)[C:11]([NH:27][C:24]2[CH:25]=[CH:26][N:21]=[CH:22][N:23]=2)=[O:13])[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

3

Reactant 2

HCID 689584-AminopyrimidineHCID 712941865-Cyclopentyl-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid

Product 1

HCID 71294419HCID 71294419, compound

Procedure

This compound was prepared following the same procedure as described in Example 11 using 5-cyclopentyl-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid (Example 9c) (100 mg, 0.35 mmol) and 4-pyrimidinamine (CAN 591-54-8, 39.5 mg, 0.41 mmol) as starting materials; off white solid (63 mg, 49.7%). MS (ESI): 367.2 (M+H)+.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-3082118158b047de914ae7066f17bb32
Source dataset
uspto-grants-2014_01
Patent number
US08629166B2

Reaction notes

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