4-Aminobenzonitrile → HCID 71294208, compound

HRID 469797Notes

Reaction equation

HRID 469797 reaction equation
[CH:1]1([C:7]2[C:8]([O:16][CH2:17][C:18]([F:21])([F:20])[F:19])=[N:9][CH:10]=[C:11]([CH:15]=2)[C:12]([OH:14])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:22][C:23]1[CH:30]=[CH:29][C:26]([C:27]#[N:28])=[CH:25][CH:24]=1>>[C:27]([C:26]1[CH:29]=[CH:30][C:23]([NH:22][C:12](=[O:14])[C:11]2[CH:15]=[C:7]([CH:1]3[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]3)[C:8]([O:16][CH2:17][C:18]([F:21])([F:20])[F:19])=[N:9][CH:10]=2)=[CH:24][CH:25]=1)#[N:28]

Participants

3

Reactant 2

HCID 133964-AminobenzonitrileHCID 712939525-Cyclohexyl-6-(2,2,2-trifluoroethoxy)nicotinic acid

Product 1

HCID 71294208HCID 71294208, compound

Procedure

This compound was prepared following the same procedure as described in Example 11 using 5-cyclohexyl-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid (Example 4b) (100 mg, 0.33 mmol) and 4-aminobenzonitrile (CAN 873-74-5, 39.0 mg, 0.33 mmol) as starting materials; off white solid (24 mg, 18.0%). MS (ESI): 402.2 (M+H)+.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-498913574e934656bff089ab83524fe8
Source dataset
uspto-grants-2014_01
Patent number
US08629166B2

Reaction notes

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