4-Aminobenzonitrile → HCID 71294342, compound

HRID 469798Notes

Reaction equation

HRID 469798 reaction equation
[CH:1]1([C:6]2[C:7]([O:15][CH2:16][C:17]([F:20])([F:19])[F:18])=[N:8][CH:9]=[C:10]([CH:14]=2)[C:11]([OH:13])=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:21][C:22]1[CH:29]=[CH:28][C:25]([C:26]#[N:27])=[CH:24][CH:23]=1>>[C:26]([C:25]1[CH:28]=[CH:29][C:22]([NH:21][C:11](=[O:13])[C:10]2[CH:14]=[C:6]([CH:1]3[CH2:2][CH2:3][CH2:4][CH2:5]3)[C:7]([O:15][CH2:16][C:17]([F:20])([F:19])[F:18])=[N:8][CH:9]=2)=[CH:23][CH:24]=1)#[N:27]

Participants

3

Reactant 2

HCID 133964-AminobenzonitrileHCID 712941865-Cyclopentyl-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid

Product 1

HCID 71294342HCID 71294342, compound

Procedure

This compound was prepared following the same procedure as described in Example 11 using 5-cyclopentyl-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid (Example 9c) (100 mg, 0.35 mmol) and 4-aminobenzonitrile (CAN 873-74-5, 49.0 mg, 0.41 mmol) as starting materials; off white solid (10 mg, 7.4%). MS (ESI): 388.2 (M+H)+.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-c6699ee54c50468d8e43e757313d363a
Source dataset
uspto-grants-2014_01
Patent number
US08629166B2

Reaction notes

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