反应详情

5 g (22.9 mmol) 2-nitro-6-bromo-phenol (Fluka 67211) is hydrogenated in the presence of 0.1 g Ra—Ni (B113W EtOH, Degussa) in 100 ml of THF:MeOH=1:1. for 4 h. The reaction mixture is filtered (2 glass fiber filters used) and the filtrate is concentrated in vacuo. The residue is purified by chromatography (silicagel, hexane:EtOAc=2:1) to afford the title compound as a reddish oil which slowly solidifies.

1. filtrationThe reaction mixture is filtered (2 glass fiber filters used)
2. concentrationthe filtrate is concentrated in vacuo
3. customThe residue is purified by chromatography (silicagel, hexane:EtOAc=2:1)