反应详情

To a solution of 0.49 g (2.01 mmol) 7-bromo-2-methylsulfanyl-benzooxazole in 30 ml dichloromethane, 3-chloroperbenzoic acid (0.494 g, 2.01 mmol) is added. This mixture is stirred for 1 h at room temperature. Then, 0.325 g (1.82 mmol) 4-amino-2,N,N-trimethyl-benzamide is added and the reaction mixture is heated to 40° C. with stirring continued for 20 h. The reaction mixture is concentrated in vacuo and the residue is purified by chromatography (silicagel, hexane:EtOAc=1:1=>1:4) to afford the title compound as an off-white crystalline solid.

1. temperaturethe reaction mixture is heated to 40° C.
2. stirringwith stirring
3. waitcontinued for 20 h
4. concentrationThe reaction mixture is concentrated in vacuo
5. customthe residue is purified by chromatography (silicagel, hexane:EtOAc=1:1=>1:4)