反应详情

2-Ethyl-7-[2-(4-nitro-phenyl)-ethyl]-2,7-diaza-spiro[4.4]nonane from above was dissolved in ethanol (60 ml) and 20% Pd(OH)2 (30 mg) was added and the reaction was stirred 16 h under an atmosphere of hydrogen gas by means of a balloon reservoir. The reaction was filtered thru Celite and the filtrate evaporated to afford 4-[2-(7-Ethyl-2,7-diaza-spiro[4.4]non-2-yl)-ethyl]-phenylamine and a crude oil (1.45 g) which was used as is in the next step.

1. filtrationThe reaction was filtered thru Celite
2. customthe filtrate evaporated