Diethyl Ether → HCID 58170422, compound

Temperature

-95 °C

To a solution of 4-bromo-2-dimethoxymethylphenol (10.0 g, 0.36 mol) in abs. ether (200 ml) n-BuLi (68 ml of 1.6 M hexane solution, 0.109 mol) was added dropwise under argon keeping the reaction mixture temperature below 25° C. Than the reaction mixture was refluxed for 3 h, then cooled to −95° C., trimethyl borate (14.3 ml, 0.128 mol) was added dropwise keeping the temperature below −95° C. After the addition was completed the temperature was increased to the RT overnight. Aqueous 1 M HCl (200 ml) was added to the stirring reaction mixture to reach pH 1.0. Organic phase was separated; aqueous phase was extracted with ether (4×50 ml). Combined organic phases were evaporated; the residue was triturated with benzene (25 ml) using an ultrasonic bath. Tan precipitate formed was collected by filtration, washed with hexane (2×10 ml) dried. Yield 2.63 g (15.8 mmol, 43%).

1. temperatureThan the reaction mixture was refluxed for 3 h
2. customthe temperature below −95° C
3. additionAfter the addition
4. temperaturewas increased to the RT overnight
5. customOrganic phase was separated
6. extractionaqueous phase was extracted with ether (4×50 ml)
7. customCombined organic phases were evaporated
8. customthe residue was triturated with benzene (25 ml)
9. customTan precipitate formed
10. filtrationwas collected by filtration
11. washwashed with hexane (2×10 ml)
12. customdried

ORD record

ord-f0b538aecf1245ef94fc8932b4757799

Source dataset

uspto-grants-2014_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08629147B2