Ammonium Chloride → 1-Chloro-3-(4-fluorophenyl)-5-methylhex-5-en-3-ol
Reaction equation
[Cl:1][CH2:2][CH2:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=1)=[O:5].[NH4+].[Cl-].I[CH2:16][C:17]([CH3:19])=[CH2:18]>C1COCC1.[Zn]>[Cl:1][CH2:2][CH2:3][C:4]([C:6]1[CH:7]=[CH:8][C:9]([F:12])=[CH:10][CH:11]=1)([OH:5])[CH2:18][C:17]([CH3:19])=[CH2:16]Participants
Procedure
A solution of 3-chloro-1-(4-fluorophenyl)-propan-1-one (18.6 g, 0.1 mol) in THF (50 mL) was added to a well-stirred suspension of zinc power (13 g, 0.2 mol) in a mixture of aqueous saturated NH4Cl solution (260 mL) and THF (65 mL). A solution of 3-iodo-2-methylprop-1-ene (36.4 g, 0.2 mol) in THF (50 mL) was added dropwise. The reaction mixture was mildly exothermic, and began to reflux spontaneously. After the refluxing had ceased, the mixture was stirred for 1 h. TLC showed the 3-chloro-1-(4-fluorophenyl)propan-1-one not reacted completely. A solution of 3-iodo-2-methylprop-1-ene (18.2 g, 0.1 mol) in THF (30 mL) was added, and the mixture was stirred at rt overnight. The mixture was extracted with EtOAc (2×500 mL). The combined organic layer was dried and concentrated. The residue was purified by column chromatography on silica gel eluted with petroleum ether/EtOAc 50:1→30:1→5:1, to give 1-chloro-3-(4-fluorophenyl)-5-methylhex-5-en-3-ol (17 g, yield 76%) as an oil.
Workup
- temperatureto reflux spontaneously
- customreacted completely
- stirringthe mixture was stirred at rt overnight
- extractionThe mixture was extracted with EtOAc (2×500 mL)
- customThe combined organic layer was dried
- concentrationconcentrated
- customThe residue was purified by column chromatography on silica gel
- washeluted with petroleum ether/EtOAc 50:1→30:1→5:1
Sources & evidence
- ORD record
- ord-4f38b12f117245faa36a886666dabb76
- Source dataset
- uspto-grants-2014_01
- Patent number
- US08629138B2
Reaction notes
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