反应详情

A mixture of 20 grams of emodin, 1000 mL of acetic acid, 82.8 grams of stannous chloride was heated to reflux. Hydrochloric acid (60 mL) was added slowly in minutes and continued reflux for 1 hour. Remaining 167 mL of HCl was added slowly at reflux and continued for an additional 1 hour. Orange color mixture was cooled to room temperature and left over night. Product was isolated by filtration and washed with water. Finally the product (emodin anthrone) was dried in vacuo at 60° C. to a constant weight to afford 18.1 grams (Yield: 95%) of an orange powder.

1. temperaturewas heated to reflux
2. temperaturecontinued reflux for 1 hour
3. additionwas added slowly
4. temperatureat reflux
5. waitleft over night
6. customProduct was isolated by filtration
7. washwashed with water
8. dry with materialFinally the product (emodin anthrone) was dried in vacuo at 60° C. to a constant weight