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HRID470678

反应详情

EQUATION

反应方程式

HRID 470678 的结构方程式

REACTANTS

反应物

2
结构：O=C(O)[C@@H]1NC2(CC(CF)(CF)C2)[C@@]2(C(=O)Nc3cc(Cl)ccc32)[C@H]1c1cccc(Cl)c1F
HCID70871764

未命名化合物

结构：N[C@H]1CC[C@H](O)CC1
HCID178511715

未命名化合物

PRODUCTS

生成物

1
结构：O=C(N[C@H]1CC[C@H](O)CC1)[C@@H]1NC2(CC(CF)(CF)C2)[C@@]2(C(=O)Nc3cc(Cl)ccc32)[C@H]1c1cccc(Cl)c1F
HCID178523814

未命名化合物

收率 67.1%

PROCEDURE

实验过程

The compound (70 mg, 0.14 mmol) obtained in Step 1 above and trans-4-aminocyclohexanol (19.4 mg, 0.17 mmol) were used as starting materials and treated in the same way as in Step 2 of Example 12 to give 56 mg (67%) of the title compound as a colorless solid.

WORKUP

后处理

  1. additiontreated in the same way as in Step 2 of Example 12