HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-3,3-bis(fluoromethyl)-2''-oxo-1'',2''-dihydrodispiro[cyclobutane-1,2'-pyrrolidine-3',3''-indole]-5'-carboxylic acid → HCID 178523814, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-3,3-bis(fluoromethyl)-2''-oxo-1'',2''-dihydrodispiro[cyclobutane-1,2'-pyrrolidine-3',3''-indole]-5'-carboxylic acid | HCID 70871764 | — |
| Reactant | HCID 178511715 | HCID 178511715 | — |
| Product | HCID 178523814 | HCID 178523814 | 67.1% |
Reaction Steps
The compound (70 mg, 0.14 mmol) obtained in Step 1 above and trans-4-aminocyclohexanol (19.4 mg, 0.17 mmol) were used as starting materials and treated in the same way as in Step 2 of Example 12 to give 56 mg (67%) of the title compound as a colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08629133B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-0e465a0bb0ec4d4a831db1c117715113 |
| Source note | uspto-grants-2014_01 |