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HRID470679

反应详情

EQUATION

反应方程式

HRID 470679 的结构方程式

REACTANTS

反应物

2
结构：O=C(O)[C@@H]1NC2(CC(CF)(CF)C2)[C@@]2(C(=O)Nc3cc(Cl)ccc32)[C@H]1c1cccc(Cl)c1F
HCID70871764

未命名化合物

结构：CN(C)C(=O)[C@H]1CC[C@H](N)CC1.Cl
HCID178484570

未命名化合物

PRODUCTS

生成物

1
结构：CN(C)C(=O)[C@H]1CC[C@H](NC(=O)[C@@H]2NC3(CC(CF)(CF)C3)[C@@]3(C(=O)Nc4cc(Cl)ccc43)[C@H]2c2cccc(Cl)c2F)CC1
HCID178484573

未命名化合物

收率 68%

PROCEDURE

实验过程

The compound (70 mg, 0.14 mmol) obtained in Step 1 of Example 121 and trans-4-amino-N,N-dimethylcyclohexanecarboxamide hydrochloride (WO2008/068171) (29 mg, 0.17 mmol) were used as starting materials and treated in the same way as in Step 2 of Example 12 to give 62 mg (68%) of the title compound as a colorless amorphous solid.

WORKUP

后处理

  1. additiontreated in the same way as in Step 2 of Example 12