(3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-3,3-bis(fluoromethyl)-2''-oxo-1'',2''-dihydrodispiro[cyclobutane-1,2'-pyrrolidine-3',3''-indole]-5'-carboxylic acid → HCID 178484573, compound

Participants

Reaction Steps

The compound (70 mg, 0.14 mmol) obtained in Step 1 of Example 121 and trans-4-amino-N,N-dimethylcyclohexanecarboxamide hydrochloride (WO2008/068171) (29 mg, 0.17 mmol) were used as starting materials and treated in the same way as in Step 2 of Example 12 to give 62 mg (68%) of the title compound as a colorless amorphous solid.

Provenance & Evidence