Ethanesulfonic acid → HCID 86672602, compound

HRID 470687Notes

Reaction equation

HRID 470687 reaction equation
[CH2:1]([S:3]([OH:6])(=[O:5])=[O:4])[CH3:2].[C:7]([C@H:10]1[O:15][CH2:14][C@H:13]([NH:16][C:17]([C@@H:19]2[NH:33][C:32]3([CH2:38][CH2:37][C:36]([CH3:40])([CH3:39])[CH2:35][CH2:34]3)[C@:21]3([C:29]4[C:24](=[CH:25][C:26]([Cl:30])=[CH:27][CH:28]=4)[NH:23][C:22]3=[O:31])[C@H:20]2[C:41]2[CH:46]=[CH:45][N:44]=[C:43]([Cl:47])[C:42]=2[F:48])=[O:18])[CH2:12][CH2:11]1)(=[O:9])[NH2:8]>CC(O)C>[OH2:4].[CH2:1]([S:3]([OH:6])(=[O:5])=[O:4])[CH3:2].[C:7]([C@H:10]1[O:15][CH2:14][C@H:13]([NH:16][C:17]([C@@H:19]2[NH:33][C:32]3([CH2:34][CH2:35][C:36]([CH3:40])([CH3:39])[CH2:37][CH2:38]3)[C@:21]3([C:29]4[C:24](=[CH:25][C:26]([Cl:30])=[CH:27][CH:28]=4)[NH:23][C:22]3=[O:31])[C@H:20]2[C:41]2[CH:46]=[CH:45][N:44]=[C:43]([Cl:47])[C:42]=2[F:48])=[O:18])[CH2:12][CH2:11]1)(=[O:9])[NH2:8]

Participants

4

Reactant 2

HCID 11668Ethanesulfonic acidHCID 73297272Milademetan

Product 1

HCID 86672602HCID 86672602, compoundYield 158%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Ethanesulfonic acid (0.024 ml, 0.30 mmol) was added to a 2-propanol (2.4 ml) solution of the compound (183 mg, 0.30 mmol) obtained in Example 70 and the resulting mixture was dissolved by heating. After stirring at room temperature for 23 hours, the precipitate was collected by filtration to give 177 mg (82%) of the title compound as a solid.

Workup

  1. dissolutionthe resulting mixture was dissolved
  2. temperatureby heating
  3. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-441b3864a889437484274c24f6d21f93
Source dataset
uspto-grants-2014_01
Patent number
US08629133B2

Reaction notes

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