Hydrazine hydrate (1:1) → HCID 178514447, compound

HRID 470711Notes

Reaction equation

HRID 470711 reaction equation
O.[NH2:2][NH2:3].[CH2:4]([O:11][C:12]([NH:14][C@H:15]1[CH2:18][C@H:17]([C:19]([O:21]C)=O)[CH2:16]1)=[O:13])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>CO>[NH:2]([C:19]([C@H:17]1[CH2:18][C@H:15]([NH:14][C:12](=[O:13])[O:11][CH2:4][C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH2:16]1)=[O:21])[NH2:3]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 178501324HCID 178501324, compound

Product 1

HCID 178514447HCID 178514447, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Hydrazine monohydrate (10 ml) was added to a methanol (50 ml) solution of methyl trans-3-{[(benzyloxy)carbonyl]amino}cyclobutanecarboxylate (Neurochemical Research, 1980, 5, 393-400) (995 mg, 3.78 mmol) at room temperature and the resulting mixture was stirred for 24 hours. The precipitated solid was collected by filtration, washed with water and then dried to give 760 mg (76%) of the title compound as a colorless solid.

Workup

  1. filtrationThe precipitated solid was collected by filtration
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-1149746f139543149e4a74049a65d4ad
Source dataset
uspto-grants-2014_01
Patent number
US08629133B2

Reaction notes

Loading…