HCID 68309439, compound → HCID 68309414, compound

HRID 470716Notes

Reaction equation

HRID 470716 reaction equation
C([NH:8][CH:9]1[CH2:12][C:11]2([CH2:15][C:14]([CH2:25][O:26]CC3C=CC=CC=3)([CH2:16][O:17]CC3C=CC=CC=3)[CH2:13]2)[CH2:10]1)C1C=CC=CC=1>[OH-].[Pd+2].[OH-].C(O)C>[NH2:8][CH:9]1[CH2:12][C:11]2([CH2:13][C:14]([CH2:16][OH:17])([CH2:25][OH:26])[CH2:15]2)[CH2:10]1

Participants

4

Reactant 1

HCID 68309439HCID 68309439, compound

Product 1

HCID 68309414HCID 68309414, compoundYield 104.8%

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Procedure

20% Palladium hydroxide (254 mg) was added to an ethanol (30 ml) solution of the compound (1.27 g, 2.88 mmol) obtained in Step 4 above and the resulting mixture was stirred at room temperature for 3 days under hydrogen atmosphere. The catalyst was removed by filtration through celite and then the filtrate was concentrated under reduced pressure to give 517 mg (99%) of the title compound as an oil.

Workup

  1. customThe catalyst was removed by filtration through celite
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-d1c76b02020e4b02ac332d2db234b08f
Source dataset
uspto-grants-2014_01
Patent number
US08629133B2

Reaction notes

Loading…