反应详情

2M HCl (4 mL) was added to a solution of (4-(2,2-diethoxyethoxy)phenyl)methanol (example 1, step g) (0.9 g) in acetone (20 mL) and the resulting mixture was stirred for 16 h at room temperature. The reaction was concentrated in vacuo and the resulting aqueous solution extracted with ethyl acetate (3×20 mL). The combined organic solutions were dried over magnesium sulphate, filtered and evaporated in vacuo to give the subtitled compound as a clear gum, which was used directly in the next step. Yield 0.50 g.

1. concentrationThe reaction was concentrated in vacuo
2. extractionthe resulting aqueous solution extracted with ethyl acetate (3×20 mL)
3. dry with materialThe combined organic solutions were dried over magnesium sulphate
4. filtrationfiltered
5. customevaporated in vacuo