反应详情

Methanesulfonyl chloride (0.18 g) in dichloromethane (0.2 mL) was added to a stirred solution of 2-(3-(diethoxymethyl)phenyl)ethanol (example 20, step c) (0.23 g) and triethylamine (0.429 mL) in dichloromethane (2.5 mL) cooled in an ice bath. After 1 h, the reaction mixture was partitioned between ethyl acetate and saturated sodium bicarbonate solution. The ethyl acetate layer was washed with saturated sodium bicarbonate solution and brine, dried over sodium sulphate, filtered and evaporated in vacuo to give the subtitled compound as a gum. Yield 0.28 g.

1. temperaturecooled in an ice bath
2. customthe reaction mixture was partitioned between ethyl acetate and saturated sodium bicarbonate solution
3. washThe ethyl acetate layer was washed with saturated sodium bicarbonate solution and brine
4. dry with materialdried over sodium sulphate
5. filtrationfiltered
6. customevaporated in vacuo