反应详情

温度

70 °C

3-(Diethoxymethyl)phenethyl methanesulfonate (example 20, step d) (0.30 g) in acetonitrile (1.5 mL) was added to a stirred solution of (5-methylthiophen-2-yl)(1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanone trifluoroacetate (example 9, step b) (0.391 g) and triethylamine (0.415 mL) in acetonitrile (1.5 mL) and the solution heated at 70° C. for 48 h. After cooling, the solution was evaporated in vacuo and applied to a silica gel column for purification, eluting with ethyl acetate:isohexane:triethylamine, 60:40:5 giving the subtitled compound as a gum. Yield 0.2 g.

1. temperatureAfter cooling
2. customthe solution was evaporated in vacuo
3. customapplied to a silica gel column for purification
4. washeluting with ethyl acetate