Toluene → HCID 67292236, compound

HRID 471031Notes

Reaction equation

HRID 471031 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH3:8][O:9][C:10]([C:12]1[S:16][C:15]([C:17]([N:19]2[CH2:24][C:23]3([CH2:29][CH2:28][N:27](C(OC(C)(C)C)=O)[CH2:26][CH2:25]3)[O:22][CH2:21][CH2:20]2)=[O:18])=[CH:14][CH:13]=1)=[O:11].C1(C)C=CC=CC=1>ClCCl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[O:22]1[C:23]2([CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH2:24][N:19]([C:17]([C:15]2[S:16][C:12]([C:10]([O:9][CH3:8])=[O:11])=[CH:13][CH:14]=2)=[O:18])[CH2:20][CH2:21]1

Participants

5

Reactant 3

HCID 1140TolueneHCID 6422Trifluoroacetic acidHCID 57988893tert-Butyl 4-(5-(methoxycarbonyl)thiophene-2-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate

Product 1

HCID 67292236HCID 67292236, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroacetic acid (10 mL) was added to a solution of tert-butyl 4-(5-(methoxycarbonyl)thiophene-2-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate (example 30, step a) (0.45 g) in dichloromethane (40 mL) and the resultant mixture was allowed to stand at 20° C. for 1 hour. Toluene (50 mL) was added and the solvents removed under reduced pressure to afford the subtitled compound. Yield 0.46 g.

Workup

  1. customthe solvents removed under reduced pressure

Sources & evidence

ORD record
ord-0af1945ffc5741c89dddc1fc87522b15
Source dataset
uspto-grants-2014_01
Patent number
US08629271B2

Reaction notes

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