反应详情

A solution of borane dimethyl sulfide (2M in THF, 18.30 mL) was added cautiously to a solution of 2-(3,4-difluorophenyl)acetic acid (2.1 g) in THF (20 mL) at 0° C. The resulting mixture was allowed to warm to RT and stirred for 1 h. The reaction was cooled in an ice bath and methanol (5 mL) was added dropwise. The reaction was stirred until bubbling ceased and the solvent evaporated in vacuo. Purification was by silica gel chromatography eluting with isohexane to 4:1 isohexane:ethyl acetate. The fractions containing product were combined and evaporated in vacuo to give the subtitled compound as a clear oil. Yield 1.92 g.

1. temperatureThe reaction was cooled in an ice bath
2. stirringThe reaction was stirred
3. customuntil bubbling
4. customthe solvent evaporated in vacuo
5. customPurification
6. washeluting with isohexane to 4:1 isohexane
7. additionThe fractions containing product
8. customevaporated in vacuo