反应详情

A solution of borane dimethyl sulfide complex (2M in THF, 26 mL) was added cautiously to a solution of 2-(2,6-difluorophenyl)acetic acid (3 g) in THF (50 mL) at 0° C. The reaction was then allowed to warm to RT and stirred for 3 h. The reaction was cooled in an ice bath and cautiously quenched with methanol (10 mL). The solvent was evaporated and the residue purified by silica gel chromatography eluting with 9:1 to 4:1 isohexane:ethyl acetate gradient. The fractions containing product were combined and evaporated to give the subtitled compound as a clear oil. Yield 2.2 g.

1. temperatureThe reaction was cooled in an ice bath
2. customcautiously quenched with methanol (10 mL)
3. customThe solvent was evaporated
4. customthe residue purified by silica gel chromatography
5. washeluting with 9:1 to 4:1 isohexane
6. additionThe fractions containing product
7. customevaporated