1-Bromo-2-Chloroethane → 7,7-Dimethyl-2-phenethyl-5-(2-chloro-ethyl)-5H,7H-imidazo-[4,5-h]isoquinoline-4,6-dione

HRID 47116Notes

Reaction equation

HRID 47116 reaction equation
[CH3:1][C:2]1([CH3:25])[C:11](=[O:12])[CH:10]2[C:5](=[C:6]3[N:16]=[C:15]([CH2:17][CH2:18][C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)[N:14]=[C:7]3[C:8](=[O:13])[CH2:9]2)[CH:4]=[N:3]1.Br[CH2:27][CH2:28][Cl:29]>>[CH3:1][C:2]1([CH3:25])[C:11](=[O:12])[CH:10]2[C:5](=[C:6]3[N:16]=[C:15]([CH2:17][CH2:18][C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)[N:14]=[C:7]3[C:8](=[O:13])[CH:9]2[CH2:27][CH2:28][Cl:29])[CH:4]=[N:3]1

Participants

3

Reactant 2

HCID 78491-Bromo-2-ChloroethaneHCID 70610353HCID 70610353, compound

Product 1

HCID 706106487,7-Dimethyl-2-phenethyl-5-(2-chloro-ethyl)-5H,7H-imidazo-[4,5-h]isoquinoline-4,6-dione

Procedure

Prepared analogous to Example 23 at room temperature from 4.3 gm of 7,7-dimethyl-2-phenethyl-5H,7H-imidazo[4,5-h]isoquinoline-4,6-dione and 2.2 gm of 2-bromo-1-chloro-ethane. The viscous oily crude product was directly further processed.

Sources & evidence

ORD record
ord-022556f42d9a42c2ac9750cf99436ef9
Source dataset
uspto-grants-1979_11
Patent number
US04176184

Reaction notes

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