1-Bromo-3-chloropropane → 7,7-Dimethyl-2-cyclohexyl-5-(3-chloro-propyl)-5H,7H-imidazo-[4,5-h]isoquinoline-4,6-dione

HRID 47118Notes

Reaction equation

HRID 47118 reaction equation
[CH3:1][C:2]1([CH3:23])[C:11](=[O:12])[CH:10]2[C:5](=[C:6]3[N:16]=[C:15]([CH:17]4[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]4)[N:14]=[C:7]3[C:8](=[O:13])[CH2:9]2)[CH:4]=[N:3]1.Br[CH2:25][CH2:26][CH2:27][Cl:28]>>[CH3:1][C:2]1([CH3:23])[C:11](=[O:12])[CH:10]2[C:5](=[C:6]3[N:16]=[C:15]([CH:17]4[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]4)[N:14]=[C:7]3[C:8](=[O:13])[CH:9]2[CH2:25][CH2:26][CH2:27][Cl:28])[CH:4]=[N:3]1

Participants

3

Reactant 2

HCID 80061-Bromo-3-chloropropaneHCID 70609678HCID 70609678, compound

Product 1

HCID 706109237,7-Dimethyl-2-cyclohexyl-5-(3-chloro-propyl)-5H,7H-imidazo-[4,5-h]isoquinoline-4,6-dione

Procedure

Prepared analogous to Example 26a from 3.1 gm of 7,7-dimethyl-2-cyclohexyl-5H,7H-imidazo[4,5-h]isoquinoline-4,6-dione and 1.9 gm of 1-bromo-3-chloro-propane. The crude product was directly further processed.

Sources & evidence

ORD record
ord-ab187f9ebedb4aebbe5d70924c7a076a
Source dataset
uspto-grants-1979_11
Patent number
US04176184

Reaction notes

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