反应详情

MCPBA (22.0 g) was added to a solution of 2-isopropylpyridine (example 85, step a) (9.1 g) in DCM (250 mL) and the resulting mixture stirred for 3 h. The reaction mixture was washed with saturated sodium bicarbonate solution (4×100 mL) and brine (100 mL), then dried over sodium sulphate, filtered and evaporated. Purification was by silica gel chromatography eluting with ethyl acetate to 10% methanol in ethyl acetate gradient. The fractions containing product were combined and evaporated to give the subtitled compound as a yellow oil. Yield 3.9 g.

1. washThe reaction mixture was washed with saturated sodium bicarbonate solution (4×100 mL) and brine (100 mL)
2. dry with materialdried over sodium sulphate
3. filtrationfiltered
4. customevaporated
5. customPurification
6. washeluting with ethyl acetate to 10% methanol in ethyl acetate gradient
7. additionThe fractions containing product
8. customevaporated