(3-Bromopropyl)diethylamine hydrobromide → 7,7-Dimethyl-2-cyclopropyl-5-(3-diethylamino-propyl)-5H,7H-imidazo[4,5-h]isoquinoline-4,6-dione

HRID 47125Notes

Reaction equation

HRID 47125 reaction equation
Cl.[CH3:2][C:3]1([CH3:21])[C:12](=[O:13])[CH:11]2[C:6](=[C:7]3[N:17]=[C:16]([CH:18]4[CH2:20][CH2:19]4)[N:15]=[C:8]3[C:9](=[O:14])[CH2:10]2)[CH:5]=[N:4]1.Br.[CH2:23]([N:25]([CH2:30][CH3:31])[CH2:26][CH2:27][CH2:28]Br)[CH3:24]>>[CH3:2][C:3]1([CH3:21])[C:12](=[O:13])[CH:11]2[C:6](=[C:7]3[N:17]=[C:16]([CH:18]4[CH2:19][CH2:20]4)[N:15]=[C:8]3[C:9](=[O:14])[CH:10]2[CH2:28][CH2:27][CH2:26][N:25]([CH2:30][CH3:31])[CH2:23][CH3:24])[CH:5]=[N:4]1

Participants

3

Reactant 2

HCID 12639158(3-Bromopropyl)diethylamine hydrobromideHCID 706098307,7-dimethyl-2-cyclopropyl-5H,7H-imidazo[4,5-h]isoquinoline-4,6-dione hydrochloride

Product 1

HCID 706111227,7-Dimethyl-2-cyclopropyl-5-(3-diethylamino-propyl)-5H,7H-imidazo[4,5-h]isoquinoline-4,6-dione

Procedure

Prepared analogous to Example 23 from 2.45 gm of 7,7-dimethyl-2-cyclopropyl-5H,7H-imidazo[4,5-h]isoquinoline-4,6-dione hydrochloride and 2.3 gm of 3-diethylamino-propyl bromide hydrobromide. The crude product was purified by chromatography on a silicagel column (eluant: chloroform with increasing content of acetone).

Workup

  1. customThe crude product was purified by chromatography on a silicagel column (eluant: chloroform with increasing content of acetone)

Sources & evidence

ORD record
ord-e2ef9d45951040e392ad9e691da19a6c
Source dataset
uspto-grants-1979_11
Patent number
US04176184

Reaction notes

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